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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM50097365
Substrate
n/a
Meas. Tech.
ChEMBL_944709 (CHEMBL2340955)
IC50
13±n/a nM
Citation
 Gobbi, S; Hu, Q; Negri, M; Zimmer, C; Belluti, F; Rampa, A; Hartmann, RW; Bisi, A Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition. J Med Chem 56:1723-9 (2013) [PubMed]  Article
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM50097365
Synonyms:
1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-carbonitrile | 1-Imidazol-1-ylmethyl-9-oxo-9H-xanthene-4-carbonitrile | CHEMBL442373
Type:
Small organic molecule
Emp. Form.:
C18H11N3O2
Mol. Mass.:
301.2988
SMILES:
O=c1c2ccccc2oc2c(ccc(Cn3ccnc3)c12)C#N
Structure:
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