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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50434230
Substrate
n/a
Meas. Tech.
ChEMBL_960944 (CHEMBL2388704)
IC50
19±n/a nM
Citation
 Das, P; Deng, X; Zhang, L; Roth, MG; Fontoura, BM; Phillips, MA; De Brabander, JK SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity. ACS Med Chem Lett 4:517-521 (2013) [PubMed]  Article
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50434230
Synonyms:
CHEMBL2385510
Type:
Small organic molecule
Emp. Form.:
C26H22FNO3
Mol. Mass.:
415.4562
SMILES:
CC(C)(C)c1ccc(Oc2ccc(cc2)-c2cc(C(O)=O)c3cc(F)ccc3n2)cc1
Structure:
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