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Target
Sodium/glucose cotransporter 1
Ligand
BDBM50441082
Substrate
n/a
Meas. Tech.
ChEMBL_985922 (CHEMBL2434757)
IC50
1956±n/a nM
Citation
 Yamamoto, Y; Kawanishi, E; Koga, Y; Sakamaki, S; Sakamoto, T; Ueta, K; Matsushita, Y; Kuriyama, C; Tsuda-Tsukimoto, M; Nomura, S N-Glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors. Bioorg Med Chem Lett 23:5641-5 (2013) [PubMed]  Article
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
  
Inhibitor
Name:
BDBM50441082
Synonyms:
CHEMBL2430319
Type:
Small organic molecule
Emp. Form.:
C23H27NO5
Mol. Mass.:
397.4642
SMILES:
CCc1ccc(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3ccccc23)cc1 |r|
Structure:
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