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Target
Thymidylate synthase
Ligand
BDBM50186267
Substrate
n/a
Meas. Tech.
ChEMBL_1340097 (CHEMBL3256243)
Ki
6500±n/a nM
Citation
 Edelman, MS; Barfknecht, RL; Huet-Rose, R; Boguslawski, S; Mertes, MP Thymidylate synthetase inhibitors. Synthesis of N-substituted 5-aminomethyl-2'-deoxyuridine 5'-phosphates. J Med Chem 20:669-73 (1977) [PubMed]
Target
Name:
Thymidylate synthase
Synonyms:
TS | TSase | TYSY_MOUSE | Tyms
Type:
PROTEIN
Mol. Mass.:
34957.15
Organism:
Mus musculus
Description:
ChEMBL_1340097
Residue:
307
Sequence:
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
  
Inhibitor
Name:
BDBM50186267
Synonyms:
2'-deoxy-5'-uridylic acid | CHEMBL211312 | dUMP
Type:
Small organic molecule
Emp. Form.:
C9H13N2O8P
Mol. Mass.:
308.1819
SMILES:
O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1ccc(=O)[nH]c1=O
Structure:
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