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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM28817
Substrate
n/a
Meas. Tech.
ChEMBL_1366448 (CHEMBL3296348)
IC50
>100000±n/a nM
Citation
 Deng, X; Kokkonda, S; El Mazouni, F; White, J; Burrows, JN; Kaminsky, W; Charman, SA; Matthews, D; Rathod, PK; Phillips, MA Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J Med Chem 57:5381-94 (2014) [PubMed]  Article
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT
Type:
Enzyme
Mol. Mass.:
42672.97
Organism:
Rattus norvegicus (rat)
Description:
The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag.
Residue:
395
Sequence:
MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
  
Inhibitor
Name:
BDBM28817
Synonyms:
5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | DSM74 | triazolopyrimidine-based compound, DSM74
Type:
Small organic molecule
Emp. Form.:
C13H10F3N5
Mol. Mass.:
293.2472
SMILES:
Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1
Structure:
Search PDB for entries with ligand similarity: