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Target
Tryptophan 5-hydroxylase 2
Ligand
BDBM50019142
Substrate
n/a
Meas. Tech.
ChEMBL_1361819 (CHEMBL3292755)
IC50
45510±n/a nM
Citation
 Fu, HJ; Zhou, YR; Bao, BH; Jia, MX; Zhao, Y; Zhang, L; Li, JX; He, HL; Zhou, XM Tryptophan hydroxylase 1 (Tph-1)-targeted bone anabolic agents for osteoporosis. J Med Chem 57:4692-709 (2014) [PubMed]  Article
Target
Name:
Tryptophan 5-hydroxylase 2
Synonyms:
Neuronal tryptophan hydroxylase | Ntph | TPH2_RAT | Tph2 | Tryptophan 5-monooxygenase 2
Type:
PROTEIN
Mol. Mass.:
55618.10
Organism:
Rattus norvegicus
Description:
ChEMBL_108365
Residue:
485
Sequence:
MQPAMMMFSSKYWARRGLSLDSAVPEEHQILGGLTQNKATASKSEDKRSGKDTSESSKTAVVFSLKNEVGGLVRALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPDNIWTEEEELEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQDAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
  
Inhibitor
Name:
BDBM50019142
Synonyms:
CHEMBL3288777
Type:
Small organic molecule
Emp. Form.:
C40H55N3O3
Mol. Mass.:
625.883
SMILES:
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(=O)NCC(=O)OCC)[C@@]1(C)Cc1nc3ccccc3nc1C2(C)C |r,t:9|
Structure:
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