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Target
Folate receptor beta
Ligand
BDBM50027658
Substrate
n/a
Meas. Tech.
ChEMBL_1431348 (CHEMBL3387474)
IC50
>1000±n/a nM
Citation
 Golani, LK; George, C; Zhao, S; Raghavan, S; Orr, S; Wallace, A; Wilson, MR; Hou, Z; Matherly, LH; Gangjee, A Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptorsa andß and the proton-coupled folate transporter. J Med Chem 57:8152-66 (2014) [PubMed]  Article
Target
Name:
Folate receptor beta
Synonyms:
FBP | FOLR2 | FOLR2_HUMAN | FR-beta | Folate receptor 2 | Folate receptor beta | Folate receptor, fetal/placental | Placental folate-binding protein
Type:
PROTEIN
Mol. Mass.:
29286.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_20077
Residue:
255
Sequence:
MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG
  
Inhibitor
Name:
BDBM50027658
Synonyms:
CHEMBL3335606
Type:
Small organic molecule
Emp. Form.:
C18H21N5O4S
Mol. Mass.:
403.455
SMILES:
Nc1nc2[nH]c(CCCc3ccc(s3)C(=O)NCCCC(O)=O)cc2c(=O)[nH]1
Structure:
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