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Target
Histone deacetylase 1
Ligand
BDBM50036933
Substrate
n/a
Meas. Tech.
ChEMBL_1434456 (CHEMBL3388273)
IC50
21000±n/a nM
Citation
 Zwick, V; Chatzivasileiou, AO; Deschamps, N; Roussaki, M; Simões-Pires, CA; Nurisso, A; Denis, I; Blanquart, C; Martinet, N; Carrupt, PA; Detsi, A; Cuendet, M Aurones as histone deacetylase inhibitors: identification of key features. Bioorg Med Chem Lett 24:5497-501 (2015) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50036933
Synonyms:
CHEMBL3355256
Type:
Small organic molecule
Emp. Form.:
C15H10O4
Mol. Mass.:
254.2375
SMILES:
Oc1cccc(\C=C2/Oc3ccccc3C2=O)c1O
Structure:
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