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Target
Acyl-CoA desaturase 1
Ligand
BDBM50060668
Substrate
n/a
Meas. Tech.
ChEMBL_1462109 (CHEMBL3396816)
IC50
21±n/a nM
Citation
 Sun, S; Zhang, Z; Pokrovskaia, N; Chowdhury, S; Jia, Q; Chang, E; Khakh, K; Kwan, R; McLaren, DG; Radomski, CC; Ratkay, LG; Fu, J; Dales, NA; Winther, MD Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors. Bioorg Med Chem 23:455-65 (2015) [PubMed]  Article
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50060668
Synonyms:
CHEMBL3394694
Type:
Small organic molecule
Emp. Form.:
C17H17F3N6O2S
Mol. Mass.:
426.416
SMILES:
Cc1nc(sc1C(=O)NCc1cccnc1)-n1cnn(CCCC(F)(F)F)c1=O
Structure:
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