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Target
Kappa-type opioid receptor
Ligand
BDBM50071073
Substrate
n/a
Meas. Tech.
ChEMBL_1468975 (CHEMBL3412632)
Ki
82±n/a nM
Citation
 Hu, M; Giulianotti, MA; McLaughlin, JP; Shao, J; Debevec, G; Maida, LE; Geer, P; Cazares, M; Misler, J; Li, L; Dooley, C; Ganno, ML; Eans, SO; Mizrachi, E; Santos, RG; Yongye, AB; Houghten, RA; Yu, Y Synthesis and biological evaluations of novel endomorphin analogues containinga-hydroxy-ß-phenylalanine (AHPBA) displaying mixedµ/d opioid receptor agonist andd opioid receptor antagonist activities. Eur J Med Chem 92:270-81 (2015) [PubMed]  Article
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50071073
Synonyms:
CHEMBL3409763
Type:
Small organic molecule
Emp. Form.:
C40H45N5O6
Mol. Mass.:
691.8152
SMILES:
Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1CCc2ccccc2C1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(N)=O |r|
Structure:
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