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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50107737
Substrate
n/a
Meas. Tech.
ChEMBL_1509302 (CHEMBL3603115)
IC50
2520±n/a nM
Citation
 Müller, SG; Heckel, A; Kley, JT; Lehmann, T; Lustenberger, P; Oost, T; Roth, GJ; Rudolf, K; Arndt, K; Lenter, M; Lotz, RR; Maier, GM; Markert, M; Schindler, M; Stenkamp, D Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414. Bioorg Med Chem Lett 25:3264-9 (2015) [PubMed]  Article
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50107737
Synonyms:
CHEMBL3600817
Type:
Small organic molecule
Emp. Form.:
C30H34FN3O2
Mol. Mass.:
487.6083
SMILES:
CC(=O)CNC1CCN(Cc2ccc(CCNC(=O)c3ccc(cc3)-c3ccc(F)cc3)cc2)CC1
Structure:
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