Reaction Details  Report a problem with these data
Target
Deoxyribonuclease-1
Ligand
BDBM50153254
Substrate
n/a
Meas. Tech.
ChEMBL_1517027 (CHEMBL3619486)
IC50
>100000±n/a nM
Citation
 Chapman, TM; Wallace, C; Gillen, KJ; Bakrania, P; Khurana, P; Coombs, PJ; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4104-8 (2015) [PubMed]  Article
Target
Name:
Deoxyribonuclease-1
Synonyms:
DNAS1_HUMAN | DNASE1 | DNL1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa
Type:
PROTEIN
Mol. Mass.:
31422.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109543
Residue:
282
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
  
Inhibitor
Name:
BDBM50153254
Synonyms:
5,6-dihydroxy-1-methyl-2-thiophen-2-yl-pyrimidine-4-carboxylic acid | 5-Hydroxy-1-methyl-6-oxo-2-thiophen-2-yl-1,6-dihydro-pyrimidine-4-carboxylic acid | 5-hydroxy-1-methyl-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid | CHEMBL366051
Type:
Small organic molecule
Emp. Form.:
C10H8N2O4S
Mol. Mass.:
252.247
SMILES:
Cn1c(nc(C(O)=O)c(O)c1=O)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: