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Target
Neurotensin receptor type 2
Ligand
BDBM50124141
Substrate
n/a
Meas. Tech.
ChEMBL_1520016 (CHEMBL3625239)
IC50
30±n/a nM
Citation
 Fanelli, R; Besserer-Offroy, É; René, A; Côté, J; Tétreault, P; Collerette-Tremblay, J; Longpré, JM; Leduc, R; Martinez, J; Sarret, P; Cavelier, F Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues. J Med Chem 58:7785-95 (2015) [PubMed]  Article
Target
Name:
Neurotensin receptor type 2
Synonyms:
Levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2 | NTR2 receptor | NTR2_HUMAN | NTSR2 | Neurotensin receptor | Neurotensin receptor 2 | Neurotensin receptor type 2
Type:
PROTEIN
Mol. Mass.:
45404.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1281495
Residue:
410
Sequence:
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
  
Inhibitor
Name:
BDBM50124141
Synonyms:
CHEMBL3622805
Type:
Small organic molecule
Emp. Form.:
C39H68N10O8Si
Mol. Mass.:
833.1049
SMILES:
CN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C[Si](C)(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
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