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Target
Peptidyl-prolyl cis-trans isomerase FKBP4
Ligand
BDBM50125333
Substrate
n/a
Meas. Tech.
ChEMBL_1519316 (CHEMBL3624907)
Ki
>50000±n/a nM
Citation
 Feng, X; Sippel, C; Bracher, A; Hausch, F Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands. J Med Chem 58:7796-806 (2015) [PubMed]  Article
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:
FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:
PROTEIN
Mol. Mass.:
51793.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154482
Residue:
459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
  
Inhibitor
Name:
BDBM50125333
Synonyms:
CHEMBL3623612
Type:
Small organic molecule
Emp. Form.:
C42H53NO11
Mol. Mass.:
747.8703
SMILES:
COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C2CCCCC2)c2cc(OC)c(OC)c(OC)c2)c2cccc(OCC(O)=O)c2)cc1OC |r|
Structure:
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