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Target
Glycogen phosphorylase, liver form
Ligand
BDBM50146091
Substrate
n/a
Meas. Tech.
ChEMBL_1554315 (CHEMBL3766854)
IC50
13580±n/a nM
Citation
 Goyard, D; Kónya, B; Chajistamatiou, AS; Chrysina, ED; Leroy, J; Balzarin, S; Tournier, M; Tousch, D; Petit, P; Duret, C; Maurel, P; Somsák, L; Docsa, T; Gergely, P; Praly, JP; Azay-Milhau, J; Vidal, S Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition. Eur J Med Chem 108:444-54 (2016) [PubMed]  Article
Target
Name:
Glycogen phosphorylase, liver form
Synonyms:
Glycogen phosphorylase, liver form | Lgp | Liver glycogen phosphorylase | PYGL_RAT | Pygl
Type:
PROTEIN
Mol. Mass.:
97489.46
Organism:
Rattus norvegicus
Description:
ChEMBL_1491377
Residue:
850
Sequence:
MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIREGWQVEEADDWLRHGNPWEKARPEFMLPVHFYGRVEHTQAGTKWVDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLQDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFGSKDGVGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWEITKKTFAYTNHTVLPEALERWPVDLVEKLLPRHLQIIYEINQKHLDRIVALFPKDIDRMRRMSLIEEEGGKRINMAHLCIVGCHAVNGVAKIHSDIVKTQVFKDFSELEPDKFQNKTNGITPRRWLLLCNPGLADLIAEKIGEDYVKDLSQLTKLHSFVGDDIFLREIAKVKQENKLKFSQFLEKEYKVKINPSSMFDVHVKRIHEYKRQLLNCLHVITMYNRIKKDPKKFFVPRTVIIGGKAAPGYHMAKMIIKLVTSVAEVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRVDDVAALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPNQPDLFKDIINMLFYHDRFKVFADYEAYVKCQEKVSQLYMNQKAWNTMVLRNIAASGKFSSDRTIREYAKDIWNMEPSDLKISLSKESSNGVNANGK
  
Inhibitor
Name:
BDBM50146091
Synonyms:
CHEMBL3765349
Type:
Small organic molecule
Emp. Form.:
C26H27NO10
Mol. Mass.:
513.4933
SMILES:
CC(=O)OC[C@H]1O[C@@]2(CC(=NO2)c2ccc3ccccc3c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O |r,c:9|
Structure:
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