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Target
Polyunsaturated fatty acid lipoxygenase ALOX15
Ligand
BDBM78048
Substrate
n/a
Meas. Tech.
ChEMBL_1556331 (CHEMBL3766390)
IC50
10000±n/a nM
Citation
 Armstrong, MM; Freedman, CJ; Jung, JE; Zheng, Y; Kalyanaraman, C; Jacobson, MP; Simeonov, A; Maloney, DJ; van Leyen, K; Jadhav, A; Holman, TR A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem 24:1183-90 (2016) [PubMed]  Article
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:
15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1)
Type:
Protein
Mol. Mass.:
74804.05
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
662
Sequence:
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMSTGGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVSLHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQHASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQPVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSVAI
  
Inhibitor
Name:
BDBM78048
Synonyms:
(6E)-6-[5-(3-fluorophenyl)-1,2-dihydropyrazol-3-ylidene]-4-methyl-1-cyclohexa-2,4-dienone | (6E)-6-[5-(3-fluorophenyl)-1,2-dihydropyrazol-3-ylidene]-4-methyl-cyclohexa-2,4-dien-1-one | (6E)-6-[5-(3-fluorophenyl)-1,2-dihydropyrazol-3-ylidene]-4-methylcyclohexa-2,4-dien-1-one | (6E)-6-[5-(3-fluorophenyl)-3-pyrazolin-3-ylidene]-4-methyl-cyclohexa-2,4-dien-1-one | 2-[5-(3-Fluoro-phenyl)-1H-pyrazol-3-yl]-4-methyl-phenol | MLS000068545 | SMR000122969 | cid_5405420
Type:
Small organic molecule
Emp. Form.:
C16H13FN2O
Mol. Mass.:
268.2856
SMILES:
Cc1ccc(O)c(c1)-c1cc([nH]n1)-c1cccc(F)c1
Structure:
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