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Target
Prostaglandin F2-alpha receptor
Ligand
BDBM50206016
Substrate
n/a
Meas. Tech.
ChEMBL_1628612 (CHEMBL3871197)
EC50
1800±n/a nM
Citation
 Sugimoto, I; Kambe, T; Okino, T; Obitsu, T; Ohta, N; Nishiyama, T; Kinoshita, A; Fujimoto, T; Egashira, H; Yamane, S; Shuto, S; Tani, K; Maruyama, T Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists. ACS Med Chem Lett 8:107-112 (2017) [PubMed]  Article
Target
Name:
Prostaglandin F2-alpha receptor
Synonyms:
PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor
Type:
Enzyme
Mol. Mass.:
40072.29
Organism:
Homo sapiens (Human)
Description:
P43088
Residue:
359
Sequence:
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
  
Inhibitor
Name:
BDBM50206016
Synonyms:
CHEMBL3889508
Type:
Small organic molecule
Emp. Form.:
C23H33NO7S
Mol. Mass.:
467.576
SMILES:
CS(=O)(=O)NC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COc1ccccc1 |r|
Structure:
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