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Target
Dual specificity protein kinase CLK4
Ligand
BDBM50208633
Substrate
n/a
Meas. Tech.
ChEMBL_1633069 (CHEMBL3875861)
IC50
130±n/a nM
Citation
 Labrière, C; Lozach, O; Blairvacq, M; Meijer, L; Guillou, C Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem 124:920-934 (2016) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57522.53
Organism:
Homo sapiens (Human)
Description:
gi_10190706
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
  
Inhibitor
Name:
BDBM50208633
Synonyms:
CHEMBL3884015
Type:
Small organic molecule
Emp. Form.:
C15H8N4
Mol. Mass.:
244.2508
SMILES:
N#Cc1cc2cnccc2c2[nH]c3ncccc3c12
Structure:
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