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Target
Dual specificity protein kinase CLK3
Ligand
BDBM50208625
Substrate
n/a
Meas. Tech.
ChEMBL_1633068 (CHEMBL3875860)
IC50
180±n/a nM
Citation
 Labrière, C; Lozach, O; Blairvacq, M; Meijer, L; Guillou, C Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. Eur J Med Chem 124:920-934 (2016) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK3
Synonyms:
CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3
Type:
Protein
Mol. Mass.:
73570.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
638
Sequence:
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
  
Inhibitor
Name:
BDBM50208625
Synonyms:
CHEMBL3885431
Type:
Small organic molecule
Emp. Form.:
C17H11N3O
Mol. Mass.:
273.2887
SMILES:
COc1cccc2c1[nH]c1c2c(cc2cnccc12)C#N
Structure:
Search PDB for entries with ligand similarity: