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Target
Substance-P receptor
Ligand
BDBM50217513
Substrate
n/a
Meas. Tech.
ChEBML_144914
IC50
28±n/a nM
Citation
 Nishi, T; Fukazawa, T; Ishibashi, K; Nakajima, K; Sugioka, Y; Iio, Y; Kurata, H; Itoh, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T Combined NK1 and NK2 tachykinin receptor antagonists: synthesis and structure-activity relationships of novel oxazolidine analogues. Bioorg Med Chem Lett 9:875-80 (1999) [PubMed]
Target
Name:
Substance-P receptor
Synonyms:
NK1R_CAVPO | Neurokinin 1 receptor | Neurokinin NK1 | TAC1R | TACR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46261.42
Organism:
GUINEA PIG
Description:
Neurokinin NK1 TACR1 GUINEA PIG::P30547
Residue:
407
Sequence:
MDNVLPVDSDLFPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPGRVVCMIEWPSHPDKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAADYEGLEMKSTRYFQTQGSVYKVSRLETTISTVVGAHEEDPEEGPKATPSSLDLTSNGSSRSNSKTVTESSSFYSNMLS
  
Inhibitor
Name:
BDBM50217513
Synonyms:
CHEMBL171658
Type:
Small organic molecule
Emp. Form.:
C34H37F2N3O6
Mol. Mass.:
621.6709
SMILES:
COc1cc(cc(OC)c1OC)C(=O)N1CO[C@@](CCN2CCC3(CC2)NC(=O)Cc2ccccc32)(C1)c1ccc(F)c(F)c1
Structure:
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