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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50219824
Substrate
n/a
Meas. Tech.
ChEMBL_157221 (CHEMBL769545)
IC50
43±n/a nM
Citation
 Billah, M; Buckley, GM; Cooper, N; Dyke, HJ; Egan, R; Ganguly, A; Gowers, L; Haughan, AF; Kendall, HJ; Lowe, C; Minnicozzi, M; Montana, JG; Oxford, J; Peake, JC; Picken, CL; Piwinski, JJ; Naylor, R; Sabin, V; Shih, NY; Warneck, JB 8-Methoxyquinolines as PDE4 inhibitors. Bioorg Med Chem Lett 12:1617-9 (2002) [PubMed]
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50219824
Synonyms:
CHEMBL444824
Type:
Small organic molecule
Emp. Form.:
C17H10Cl2N4O2
Mol. Mass.:
373.193
SMILES:
COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C#N
Structure:
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