Reaction Details  Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-2
Ligand
BDBM50000766
Substrate
n/a
Meas. Tech.
ChEMBL_1646145 (CHEMBL3995201)
Ki
20±n/a nM
Citation
 Cherukupalli, S; Karpoormath, R; Chandrasekaran, B; Hampannavar, GA; Thapliyal, N; Palakollu, VN An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. Eur J Med Chem 126:298-352 (2017) [PubMed]  Article
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA A Alpha2Beta2Gamma2 | GABA A alpha2 | GABA A receptor alpha-2/beta-2/gamma-2 | GABA receptor alpha-2 subunit | GABA(A) receptor subunit alpha-2 | GBRA2_RAT | Gabra-2 | Gabra2 | Gamma-aminobutyric acid receptor subunit alpha-2
Type:
Enzyme
Mol. Mass.:
51195.57
Organism:
Rattus norvegicus (Rat)
Description:
P23576
Residue:
451
Sequence:
MRTKLSTCNVWFPLLVLLVWNPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNSMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNPSDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
  
Inhibitor
Name:
BDBM50000766
Synonyms:
CHEMBL12 | DIAZEPAM | US9271961, Diazepam
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O
Mol. Mass.:
284.74
SMILES:
CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10|
Structure:
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