Reaction Details  Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-6
Ligand
BDBM50243981
Substrate
n/a
Ki
2053±n/a nM
Comments
PDSP_1225
Citation
 Hadingham, KL; Garrett, EM; Wafford, KA; Bain, C; Heavens, RP; Sirinathsinghji, DJ; Whiting, PJ Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. Mol Pharmacol 49:253-9 (1996) [PubMed]
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-6
Synonyms:
GABA A alpha6 | GABA receptor alpha-6 subunit | GABRA6 | GBRA6_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51029.60
Organism:
Homo sapiens (Human)
Description:
GABA A alpha6 0 HUMAN::Q16445
Residue:
453
Sequence:
MASSLPWLCIILWLENALGKLEVEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQFAAPPTVTISKATEPLEAEIVLHPDSKYHLKKRITSLSLPIVSSSEANKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVYLSKDTMEVSSSVE
  
Inhibitor
Name:
BDBM50243981
Synonyms:
Beta CCM | CHEMBL453066 | Methyl Beta-carboline-3 carboxylate | methyl 9H-pyrido[3,4-b]indole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C13H10N2O2
Mol. Mass.:
226.2307
SMILES:
COC(=O)c1cc2c(cn1)[nH]c1ccccc21
Structure:
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