Reaction Details  Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-6
Ligand
BDBM50017009
Substrate
n/a
Ki
34.3±n/a nM
Comments
PDSP_502
Citation
 Gunnersen, D; Kaufman, CM; Skolnick, P Pharmacological properties of recombinant "diazepam-insensitive" GABAA receptors. Neuropharmacology 35:1307-14 (1996) [PubMed]  Article
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-6
Synonyms:
GABA A Alpha6Beta3Gamma2 | GABA A receptor alpha-6/beta-2/gamma-2 | GABA receptor alpha-6 subunit | GBRA6_RAT | Gabra-6 | Gabra6 | Gamma-aminobutyric acid receptor subunit alpha-6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51188.24
Organism:
RAT
Description:
GABA A Alpha6Beta2Gamma2 0 RAT::P30191
Residue:
453
Sequence:
MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE
  
Inhibitor
Name:
BDBM50017009
Synonyms:
2-Phenyl-2,3a-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one (CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS 8216) | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]quinolin-3-one(CGS-8216) | 2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one | CGS 8216, 1 | CGS-8216 | CHEMBL19732
Type:
Small organic molecule
Emp. Form.:
C16H11N3O
Mol. Mass.:
261.278
SMILES:
O=c1n([nH]c2c1cnc1ccccc21)-c1ccccc1
Structure:
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