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Target
Gastrin-releasing peptide receptor
Ligand
BDBM50063814
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_702
Citation
 Katsuno, T; Pradhan, TK; Ryan, RR; Mantey, SA; Hou, W; Donohue, PJ; Akeson, MA; Spindel, ER; Battey, JF; Coy, DH; Jensen, RT Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R). Biochemistry 38:7307-20 (1999) [PubMed]  Article
Target
Name:
Gastrin-releasing peptide receptor
Synonyms:
GRPR_RAT | Gastrin-Releasing peptide | Gastrin-releasing peptide receptor | Grpr
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43227.55
Organism:
RAT
Description:
Gastrin-Releasing peptide 0 RAT::P52500
Residue:
384
Sequence:
MDPNNCSHLNLEVDPFLSCNNTFNQTLSPPKMDNWFHPGIIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYIIPLSIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFITSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPSLLNRSHSTGRSTTCMTSFKSTNPSATFSLINGNICHEGYV
  
Inhibitor
Name:
BDBM50063814
Synonyms:
CHEMBL217438 | Dnal,Cys,Tyr,DTrp,Lys,Val,Cys,Nal-nh2 | H-DNal-cyclo[Cys-Tyr-DTrp-Lys-Val-DCys]-Nal-NH2 | H-DNal-cyclo[DCys-Tyr-DTrp-Lys-Val-Cys]-DNal-NH2 | H-DNal-cyclo[DCys-Tyr-DTrp-Lys-Val-Cys]-Nal-NH2 | H-Nal-cyclo[DCys-Tyr-DTrp-Lys-Val-Cys]-Nal-NH2
Type:
Small organic molecule
Emp. Form.:
C63H73N11O9S2
Mol. Mass.:
1192.452
SMILES:
CC(C)[C@@H]1NC(=O)[C@@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O)NC(=O)[C@H](N)Cc1ccc2ccccc2c1
Structure:
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