Reaction Details  Report a problem with these data
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM92605
Substrate
n/a
Meas. Tech.
Continuous Assay
IC50
2.8e+2± 1e+1 nM
Citation
 Patel, V; Booker, M; Kramer, M; Ross, L; Celatka, CA; Kennedy, LM; Dvorin, JD; Duraisingh, MT; Sliz, P; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 283:35078-85 (2008) [PubMed]  Article
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative
Type:
PROTEIN
Mol. Mass.:
62972.27
Organism:
Plasmodium vivax
Description:
A5K1N1
Residue:
572
Sequence:
MLRHSCLREKGNLIGGSLLRGISAQLRAAGGGTFRSFHSYRSFCSFCIFRRANKADANWYGCFPGHVAGGATCGPLRGDCAERHKLMAHVRRFSGESTRAKGGDKREGDIEGNRTNGSDKTKQLEEEMKKLNEQIAREKGNHKKALLFIFTCVVALYMYFESYDPEFFLYDVFLKMLLKYVDGETCHELFLLMGKYKLLPYDTGKDNIYSCSEIKGLNFINPFGVAAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGCDEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQDLSYCIGKIGRYADYIAINVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVVGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKLGDAVGRAHRRAA
  
Inhibitor
Name:
BDBM92605
Synonyms:
DHOD Inhibitor, 4 | US8703811, 5
Type:
Small molecule
Emp. Form.:
C16H16N2OS2
Mol. Mass.:
316.441
SMILES:
O=C(NC1CC1)c1ccc(s1)N1CCSc2ccccc12
Structure:
Search PDB for entries with ligand similarity: