Reaction Details  Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase A
Ligand
BDBM92920
Substrate
n/a
Meas. Tech.
PPIase Assay
pH
7.8±n/a
Temperature
278.15±n/a K
Ki
>1.00e+5±n/a nM
Comments
extracted
Citation
 Daum, S; Schumann, M; Mathea, S; Aumüller, T; Balsley, MA; Constant, SL; de Lacroix, BF; Kruska, F; Braun, M; Schiene-Fischer, C Isoform-specific inhibition of cyclophilins. Biochemistry 48:6268-77 (2009) [PubMed]  Article
Target
Name:
Peptidyl-prolyl cis-trans isomerase A
Synonyms:
CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A
Type:
Protein
Mol. Mass.:
18015.32
Organism:
Homo sapiens (Human)
Description:
P62937
Residue:
165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTEWLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
  
Inhibitor
Name:
BDBM92920
Synonyms:
Benzofuranone, 9
Type:
Small molecule
Emp. Form.:
C17H14O3
Mol. Mass.:
266.2913
SMILES:
COc1ccc2OC3(Cc4ccccc4C3)C(=O)c2c1
Structure:
Search PDB for entries with ligand similarity: