Reaction Details 
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Protein Wnt-3a
Ligand
BDBM54572
Substrate
n/a
IC50
2840±n/a nM
Citation
PubChem, PC Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay PubChem Bioassay (2012)[AID]More Info.:
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor
Type:
PROTEIN
Mol. Mass.:
39269.29
Organism:
Mus musculus
Description:
ChEMBL_813156
Residue:
352
Sequence:
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
Inhibitor
Name:
BDBM54572
Synonyms:
1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-pentanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pentan-1-one | 1-[4-(2,5-dimethylphenyl)piperazino]-5-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pentan-1-one | KUC103399N | UNM-0000306116 | cid_42628042
Type:
Small organic molecule
Emp. Form.:
C26H32N4O3
Mol. Mass.:
448.5573
SMILES:
COc1ccc(cc1)-c1noc(CCCCC(=O)N2CCN(CC2)c2cc(C)ccc2C)n1
Structure:
