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Target
Nuclear hormone receptor family member daf-12
Ligand
BDBM49507
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify agonists of the DAF-12 from the parasite H. contortus (hcDAF-12)
EC50
67537±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify agonists of the DAF-12 from the parasite H. contortus (hcDAF-12) PubChem Bioassay (2013)[AID]
Target
Name:
Nuclear hormone receptor family member daf-12
Synonyms:
DAF12_CAEEL | Protein DAF-12, isoform a | XL285 | daf-12 | daf-20 | mig-7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
84211.49
Organism:
Caenorhabditis elegans
Description:
gi_71987181
Residue:
753
Sequence:
MGTNGGVIAEQSMEIETNENPDKVEEPVVRRKRVTRRRHRRIHSKNNCLTPPNSDDDPQMSTPDDPVIHSPPSIGAAPGMNGYHGSGVKLEESSGACGSPDDGLLDSSEESRRRQKTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRKNSRLNNTGTCNKRSQPGNQQSPQGPNQQPHLSPHHPGVAIYPPQPQRPLTINPMDNQMMHHMQANRPNAMPQLISPPGAQPYPLTSPVGSSASDSPPNRSLTMMHNGEKSPDGYDPNIMAHRAPPPSFNNRPKMDSGQVVLSTEEYKQLLSRIPGAQVPGLMNEEEPINKRAAYNCNGHPMPAETTPPYSAPMSDMSLSRHNSTSSGTEKNHMTHSTVSAIPGNSAQNHFDIASFGMGIVTATGGGDAAEEMYKRMNMFYENCIQSALDSPENQEPKPQEAMIPKEEYMTPTHGFQYQSDPYQVPPAERNINYQLNAAELKALDAVREAFYGMDDPMEQGRQMQSFLKANKTPADIMNIMDVTMRRFVKVAKGVPAFREVSQEGKFSLLKGGMIEMLTVRGVTRYDASTNSFKTPTIKGQNVSVNVDDMFAKLNANAQAQKAKCLEFFGFFDEEIKKNELAVYLVMLAVLFSVRSDPPMNENDVRIVTERHNHFMSLLNRYLESLFGEQARRIFERIPKALGLLNEIARNAGMLFMGTVRSGEAEELPGEFFKIK
  
Inhibitor
Name:
BDBM49507
Synonyms:
4H-3,1-benzothiazin-2-yl-(4-methylbenzyl)amine | MLS000543331 | N-(4-methylbenzyl)-4H-3,1-benzothiazin-2-amine | N-[(4-methylphenyl)methyl]-4H-3,1-benzothiazin-2-amine | SMR000169300 | cid_3721736
Type:
Small organic molecule
Emp. Form.:
C16H16N2S
Mol. Mass.:
268.377
SMILES:
Cc1ccc(CN=C2Nc3ccccc3CS2)cc1 |w:6.5|
Structure:
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