Reaction Details  Report a problem with these data
Target
Dihydroorotate dehydrogenase (fumarate)
Ligand
BDBM92605
Substrate
n/a
Meas. Tech.
Enzymatic Assays
IC50
>10000±n/a nM
Citation
 Bastos, C; Booker, ML; Celatka, CA; Clardy, JC; Cortese, J; Patel, VP; Skerlj, R; Wiegand, RC; Wirth, DF Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase US Patent  US8703811 Publication Date 4/22/2014
Target
Name:
Dihydroorotate dehydrogenase (fumarate)
Synonyms:
Dihydroorotate dehydrogenase | PYRD_YEAST | URA1
Type:
Enzyme
Mol. Mass.:
34799.00
Organism:
Saccharomyces cerevisiae
Description:
P28272
Residue:
314
Sequence:
MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI
  
Inhibitor
Name:
BDBM92605
Synonyms:
DHOD Inhibitor, 4 | US8703811, 5
Type:
Small molecule
Emp. Form.:
C16H16N2OS2
Mol. Mass.:
316.441
SMILES:
O=C(NC1CC1)c1ccc(s1)N1CCSc2ccccc12
Structure:
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