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Target
RNA-editing ligase 1, mitochondrial
Ligand
BDBM34972
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1).
IC50
>96559±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). PubChem Bioassay (2014)[AID]
Target
Name:
RNA-editing ligase 1, mitochondrial
Synonyms:
REL1 | RLGM1_TRYBB | Trypanosoma brucei RNA editing ligase 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52299.36
Organism:
Trypanosoma brucei brucei
Description:
gi_342179211
Residue:
469
Sequence:
MQLQRLGAPLLKRLVGGCIRQSTAPIMPCVVVSGSGVFLTPVRTYMPLPNDQSDFSPYIEIDLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLNGELFGAKYKHPLVPKSEKWCTLPNGKKFPIAGVQIQREPFPQYSPELHFFAFDIKYSVSGAEEDFVLLGYDEFVEFSSKVPNLLYARALVRGTLDECLAFDVENFMTPLPALLGLGNYPLEGNLAEGVVIRHVRRGDPAVEKHNVSTIIKLRCSSFMELKHPGKQKELKETFIDTVRSGALRRVRGNVTVISDSMLPQVEAAANDLLLNNVSDGRLSNVLSKIGREPLLSGEVSQVDVVLMLAKDALKDFLKEVDSLVLNTTLAFRKLLITNVYFESKRLVEQKWKELMQEEAAAQSEAIPPLSPAAPTKGE
  
Inhibitor
Name:
BDBM34972
Synonyms:
MLS000759648 | N''-[(E)-(2,3-dihydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-2-[2-(4-morpholinyl)-4-thiazolyl]acetohydrazide | N''-[(E)-(2,3-dihydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-(2-morpholin-4-yl-1,3-thiazol-4-yl)acetohydrazide | N''-[(E)-[2,3-bis(oxidanyl)-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene]methyl]-2-(2-morpholin-4-yl-1,3-thiazol-4-yl)ethanehydrazide | N''-[(Z)-(2,3-dihydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-2-(2-morpholinothiazol-4-yl)acetohydrazide | N'-[(E)-(2,3-dihydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-2-(2-morpholinothiazol-4-yl)acetohydrazide | N'-[(Z)-(2,3-dihydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-2-(2-morpholinothiazol-4-yl)acetohydrazide | SMR000369439 | cid_6508305
Type:
Small organic molecule
Emp. Form.:
C16H18N4O5S
Mol. Mass.:
378.403
SMILES:
Oc1ccc(C=NNC(=O)Cc2csc(n2)N2CCOCC2)c(O)c1O |w:6.6|
Structure:
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