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Target
Sodium-dependent dopamine transporter
Ligand
BDBM160622
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.9±n/a
Temperature
277.15±n/a K
IC50
25.5±n/a nM
Comments
extracted
Citation
 Guzzo, PR; Liu, S; Ryan, KN; Molino, BF; DeOrazio, R; Olson, RE; Macor, JE 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin US Patent  US9045468 Publication Date 6/2/2015
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM160622
Synonyms:
US9045468, 38
Type:
Small organic molecule
Emp. Form.:
C25H20Cl2N2O2
Mol. Mass.:
451.345
SMILES:
Clc1ccc(cc1Cl)C12CCN(CC1)Cc1cc(ccc21)-c1ccc2[nH]c(=O)oc2c1 |(3.21,5.77,;3.61,4.28,;2.52,3.19,;2.92,1.7,;4.41,1.3,;5.5,2.39,;5.1,3.88,;6.19,4.97,;4.81,-.18,;6.31,-.53,;6.98,-1.92,;6.31,-3.3,;5.95,-1.67,;4.41,-1.67,;4.81,-3.65,;3.6,-2.69,;2.27,-3.46,;.94,-2.69,;.94,-1.15,;2.27,-.38,;3.6,-1.15,;-.4,-3.46,;-.4,-5,;-1.73,-5.77,;-3.07,-5,;-4.53,-5.47,;-5.44,-4.23,;-6.98,-4.23,;-4.53,-2.98,;-3.07,-3.46,;-1.73,-2.69,)|
Structure:
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