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Target
Tyrosine-protein kinase ABL1 [229-512]
Ligand
BDBM185676
Substrate
n/a
Meas. Tech.
End Point Fluorescence Assay
pH
8±n/a
Kd
0.75±0.0 nM
Comments
extracted
Citation
 Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol 11:1296-304 (2016) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase ABL1 [229-512]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl)
Type:
Protein
Mol. Mass.:
32850.19
Organism:
Homo sapiens (Human)
Description:
Human c-Abl kinase domain (229-512aa)
Residue:
284
Sequence:
SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
  
Inhibitor
Name:
BDBM185676
Synonyms:
DAS-DFGO-II-BODIPY
Type:
Small organic molecule
Emp. Form.:
C42H40BF5N10O3S
Mol. Mass.:
870.7
SMILES:
Cc1cc(C)n2c1C=C1C=CC(CCC(=O)N3CCN(CC3)c3cc(Nc4ncc(s4)C(=O)Nc4cc(NC(=O)c5cccc(c5)C(F)(F)F)ccc4C)nc(C)n3)=[N+]1[B-]2(F)F |c:10,63,t:8|
Structure:
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