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Target
Beta-galactosidase [24-677]
Ligand
BDBM228805
Substrate
4-Methylumbelliferyl-β-D-galactopyranoside
Meas. Tech.
β-Gal Inhibitory Assay
pH
4.5±n/a
Temperature
310.15±n/a K
Ki
4.140e+6±n/a nM
Citation
 Suzuki, H; Ohto, U; Higaki, K; Mena-Barragán, T; Aguilar-Moncayo, M; Ortiz Mellet, C; Nanba, E; Garcia Fernandez, JM; Suzuki, Y; Shimizu, T Structural basis of pharmacological chaperoning for human ß-galactosidase. J Biol Chem 289:14560-8 (2014) [PubMed]  Article
Target
Name:
Beta-galactosidase [24-677]
Synonyms:
BGAL_HUMAN | ELNR1 | GLB1 | beta-Galactosidase (β-Gal)
Type:
Enzyme
Mol. Mass.:
73588.24
Organism:
Homo sapiens (Human)
Description:
Human β-Gal (24-677 aa)
Residue:
654
Sequence:
LRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
  
Inhibitor
Name:
BDBM228805
Synonyms:
Galactose
Type:
Small organic molecule
Emp. Form.:
C6H12O6
Mol. Mass.:
180.1559
SMILES:
OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM50361738
Synonyms:
CHEMBL1393422
Type:
Small organic molecule
Emp. Form.:
C16H18O8
Mol. Mass.:
338.3093
SMILES:
Cc1cc(=O)oc2cc(O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)ccc12
Structure:
Search PDB for entries with ligand similarity: