Target

Ligand

Substrate

Meas. Tech.

Kinase Inhibition Assay

Citation

 Kuo, GH; Prouty, C; Wang, A; Emanuel, S; Deangelis, A; Zhang, Y; Song, F; Beall, L; Connolly, PJ; Karnachi, P; Chen, X; Gruninger, RH; Sechler, J; Fuentes-Pesquera, A; Middleton, SA; Jolliffe, L; Murray, WV Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors. J Med Chem 48:4892-909 (2005) [PubMed]  Article

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Glycogen synthase kinase-3 beta [7-25]

Synonyms:

G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta

Type:

Enzyme fragment

Mol. Mass.:

1972.14

Organism:

Oryctolagus cuniculus (rabbit)

Description:

Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli.. Only partial sequence is available.

Residue:

19

Sequence:

TTSFAESCKPVQQPSAFGS

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM6419

Synonyms:

N-(3-Chlorophenyl)-6-[5-[[3-(3-pyridinyl)propyl]amino]-3-pyridinyl]-2-pyrazinamine | N-(3-chlorophenyl)-6-(5-{[3-(pyridin-3-yl)propyl]amino}pyridin-3-yl)pyrazin-2-amine | Pyrazine-Pyridine Biheteroaryl 56

Type:

Small organic molecule

Emp. Form.:

C23H21ClN6

Mol. Mass.:

416.906

SMILES:

Clc1cccc(Nc2cncc(n2)-c2cncc(NCCCc3cccnc3)c2)c1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

GSK-3 Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

3277.76

Organism:

n/a

Description:

n/a

Residue:

27

Sequence:

ITINKRREILSRRPPHSPHSYRAMIDE