Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM238311
Substrate
n/a
Meas. Tech.
CA Activity Assay
IC50
5.77e+4±n/a nM
Citation
 Büyükkidan, N; Büyükkidan, B; Bülbül, M; Özer, S; Gonca Yalçin, H Synthesis and characterization of phenolic Mannich bases and effects of these compounds on human carbonic anhydrase isozymes I and II. J Enzyme Inhib Med Chem 28:337-42 (2013) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM238311
Synonyms:
2-((dibenzylamino)methyl)-4,5-dimethylphenol (2e)
Type:
Small organic molecule
Emp. Form.:
C23H25NO
Mol. Mass.:
331.4507
SMILES:
Cc1cc(O)c(CN(Cc2ccccc2)Cc2ccccc2)cc1C
Structure:
Search PDB for entries with ligand similarity: