Reaction Details  Report a problem with these data
Target
Polyphenol oxidase 1
Ligand
BDBM50219502
Substrate
n/a
Meas. Tech.
Tyrosinase Inhibition Assay
pH
6.8±0
Temperature
310.15±0 K
IC50
3.20e+5± 1.5e+4 nM
Citation
 Kim, SS; Hyun, CG; Choi, YH; Lee, NH Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz. J Enzyme Inhib Med Chem 28:685-9 (2013) [PubMed]  Article
Target
Name:
Polyphenol oxidase 1
Synonyms:
PPO1 | PPO1_AGABI | Polyphenol oxidase | Tyrosinase
Type:
Enzyme
Mol. Mass.:
63902.83
Organism:
Agaricus bisporus (White button mushroom)
Description:
Q00024
Residue:
568
Sequence:
MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYPLIPFDDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNKSEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNSVNDGGFYGPYNQWDTTLRQPDSTGVNAKDNVNRLKSVLKNAQASLTRATYDMFNRVTTWPHFSSHTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAPFDPIFFLHHANVDRLIALWSAIRYDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVGLDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRPAKRSRLGQLLKGLFSDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEIGFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELTDDEPNPRSRPPRYHKDITHGKRGGCREA
  
Inhibitor
Name:
BDBM50219502
Synonyms:
4-hydroxyphenyl beta-D-glucopyranoside | Arbutin | CHEMBL232202 | hydroquinone O-beta-D-glucopyranoside | p-hydroxyphenyl beta-D-glucopyranoside | p-hydroxyphenyl beta-D-glucoside
Type:
Small organic molecule
Emp. Form.:
C12H16O7
Mol. Mass.:
272.2512
SMILES:
OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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