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Target
Neutrophil elastase
Ligand
BDBM241999
Substrate
n/a
Meas. Tech.
Elastase Activity Assay
IC50
125± 2 nM
Citation
 Sokmen, BB; Aydin, G; Gumus, A; Karadeniz, S; Ugras, HI; Yanardag, R; Cakir, U Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines. J Enzyme Inhib Med Chem 28:870-5 (2013) [PubMed]  Article
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM241999
Synonyms:
4,4'-(Ethane-1,2-diylbis(phenylazanediyl))bis(methylene)bis(6,7-dihydroxy-2H-chromen-2-one) (7)
Type:
Small organic molecule
Emp. Form.:
C25H24N2O4
Mol. Mass.:
416.4691
SMILES:
CN(CCN(Cc1cc(=O)oc2c(O)c(O)ccc12)c1ccccc1)c1ccccc1
Structure:
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