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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM294073
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
Temperature
303.15±n/a K
IC50
5810±0.76 nM
Comments
extracted
Citation
 Martinez Gil, A; Ayuso-Gontan, CG; Palomo Ruiz, V; Perez Martin, C; Perez Fernandez, DI; Reyes Rodriguez, JA Heterocyclic GSK-3 allosteric modulators US Patent  US9585879 Publication Date 3/7/2017
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM294073
Synonyms:
6-Fluoro-N′-dodecanoyl-4-hydroxy-2-oxo-2-hydroquinoline-3-carbohydrazide | US9585879, 17
Type:
Small organic molecule
Emp. Form.:
C21H27FN3O4
Mol. Mass.:
404.4552
SMILES:
CCCCCCCCCCC(=O)NNC(=O)c1c(O)c2c(F)cccc2nc1=O
Structure:
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