Reaction Details  Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM423319
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
>2000±n/a nM
Citation
 Chen, Y; Dou, F; Qiu, Y; Yu, M; Zhang, G Lactam compound derivative and application thereof US Patent  US10501452 Publication Date 12/10/2019
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM423319
Synonyms:
US10501452, Compound 25
Type:
Small organic molecule
Emp. Form.:
C25H29FN2O3
Mol. Mass.:
424.5078
SMILES:
CN1CCc2ccc(OCCCN3CCC(CC3)C(=O)c3ccc(F)cc3)cc2C1=O
Structure:
Search PDB for entries with ligand similarity: