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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50337838
Substrate
n/a
Meas. Tech.
Functional Uptake Assay (rSERT)
IC50
110±n/a nM
Citation
 Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent  US10562878 Publication Date 2/18/2020
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM50337838
Synonyms:
1-(1-(3,4-dichlorophenyl)cyclohexyl)-N-methylmethanamine | CHEMBL1683870 | US10562878, Compound 75
Type:
Small organic molecule
Emp. Form.:
C14H19Cl2N
Mol. Mass.:
272.213
SMILES:
CNCC1(CCCCC1)c1ccc(Cl)c(Cl)c1
Structure:
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