Reaction Details  Report a problem with these data
Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM321336
Substrate
n/a
Meas. Tech.
In Vitro Functional Activity (Agonism) on Human S1P5 Receptors
EC50
25.1±n/a nM
Citation
 Stoit, A; Iwema Bakker, WI; Coolen, HK; van Dongen, MJ; Leflemme, NJ; Hobson, A Spiro-cyclic amine derivatives as S1P modulators US Patent  US10807991 Publication Date 10/20/2020
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM321336
Synonyms:
US10179791, Compound 303 | US10807991, Compound 303
Type:
Small organic molecule
Emp. Form.:
C23H23NO3
Mol. Mass.:
361.4336
SMILES:
OC(=O)CCN1CCC2(COc3cc(ccc23)C#Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: