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Target
Nuclear receptor ROR-gamma
Ligand
BDBM491945
Substrate
n/a
Meas. Tech.
ThermoFluor Assay
Kd
0.170±n/a nM
Citation
 Goldberg, S; McClure, K; Tanis, VM; Fennema, EG; Lebsack, AD; Martin, CL; Venkatesan, H; Xue, X; Woods, CR 6-aminopyridin-3-yl thiazoles as modulators of RORγT US Patent  US10975068 Publication Date 4/13/2021
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM491945
Synonyms:
(S)—N-(2-Hydroxy-2-methylpropyl)-4-(2-methylpiperidine-1-carbonyl)-5-(6-(neopentylamino)-4-(trifluoromethyl)pyridin-3-yl)thiazole-2-carboxamide | US10975068, Example 86
Type:
Small organic molecule
Emp. Form.:
C26H36F3N5O3S
Mol. Mass.:
555.656
SMILES:
C[C@H]1CCCCN1C(=O)c1nc(sc1-c1cnc(NCC(C)(C)C)cc1C(F)(F)F)C(=O)NCC(C)(C)O |r|
Structure:
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