Reaction Details 
Report a problem with these data
Report a problem with these dataTarget
Glycogen synthase kinase-3 beta [7-25]
Ligand
BDBM7793
Substrate
GSK-3 Peptide Substrate
Meas. Tech.
GSK-3 Inhibition Assay
Temperature
310.15±n/a K
IC50
3000±n/a nM
Comments
extracted
Citation
Martinez, A; Alonso, M; Castro, A; Perez, C; Moreno, FJ First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease. J Med Chem 45:1292-9 (2002) [PubMed] ArticleMore Info.:
Target
Name:
Glycogen synthase kinase-3 beta [7-25]
Synonyms:
G1T8E2_RABIT | GSK-3, beta | GSK3B | Glycogen Synthase Kinase-3, beta
Type:
Enzyme fragment
Mol. Mass.:
1972.14
Organism:
Oryctolagus cuniculus (rabbit)
Description:
Glycogen Synthase Kinase-3 is the beta isoform of the rabbit enzyme produced in E.coli..
Only partial sequence is available.
Residue:
19
Sequence:
TTSFAESCKPVQQPSAFGS
Inhibitor
Name:
BDBM7793
Synonyms:
2-methyl-4-(1-naphthyl)-1,2,4-thiadiazolidine-3,5-dione | 2-methyl-4-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione | Thiadiazolidinone (TDZD) deriv. 20
Type:
Small organic molecule
Emp. Form.:
C13H10N2O2S
Mol. Mass.:
258.296
SMILES:
Cn1sc(=O)n(-c2cccc3ccccc23)c1=O |(-2.2,-2.25,;-1.3,-1,;.25,-1,;.72,.46,;2.05,1.23,;-.52,1.37,;-.52,2.91,;-1.86,3.68,;-1.86,5.22,;-.52,5.99,;.75,5.22,;2.08,5.99,;3.42,5.22,;3.42,3.68,;2.08,2.91,;.75,3.68,;-1.77,.46,;-3.24,.94,)|
Structure:
Substrate
Name:
GSK-3 Peptide Substrate
Synonyms:
GS-1 Peptide | Phospho-GS2 Substrate Peptide
Type:
Peptide
Mol. Mass.:
3045.17
Organism:
n/a
Description:
n/a
Residue:
27
Sequence:
YRRAAVPPSPSLSRHSSPHQSPEDEEE