Reaction Details  Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [265-330]
Ligand
BDBM518375
Substrate
n/a
Meas. Tech.
Biological Assay
Ki
<25000±n/a nM
Citation
 Cosford, ND; Vamos, MD Inhibitor of apoptosis protein (IAP) antagonists US Patent  US11111270 Publication Date 9/7/2021
Target
Name:
E3 ubiquitin-protein ligase XIAP [265-330]
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP/ BIR 3 | IAP3 | XIAP | XIAP_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
7652.55
Organism:
Homo sapiens (Human)
Description:
P98170[265-330]
Residue:
66
Sequence:
YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL
  
Inhibitor
Name:
BDBM518375
Synonyms:
US11111270, Compound 40
Type:
Small organic molecule
Emp. Form.:
C42H58N8O8S2
Mol. Mass.:
867.089
SMILES:
CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)C(N2C1=O)C(=O)Nc1ccccc1SSc1ccccc1NC(=O)C1N2[C@H](CC1(C)C)OCC[C@H](NC(=O)[C@H](C)NC)C2=O |r,w:16.21,40.43|
Structure:
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