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Target
Vascular endothelial growth factor A
Ligand
BDBM566628
Substrate
n/a
Meas. Tech.
VEGF ELISA Assay
EC50
7.00±n/a nM
Citation
 Fu, J; Lou, Y; He, Y Hypoxia inducible factor-2(alpha) inhibitors and their use in the treatment of diseases US Patent  US11420936 Publication Date 8/23/2022
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
395
Sequence:
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM566628
Synonyms:
(R)-3-fluoro-5-((3,3,4,4-tetrafluoro-2a-hydroxy-1- methylene-2,2a,3,4-tetrahydro-1H- cyclopenta[cd]inden-7-yl)oxy)benzonitrile | US11420936, Compound 23a
Type:
Small organic molecule
Emp. Form.:
C19H10F5NO2
Mol. Mass.:
379.2802
SMILES:
O[C@]12CC(=C)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F |r|
Structure:
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