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Target
Rho-associated protein kinase 2 [1-119]
Ligand
BDBM402405
Substrate
n/a
Meas. Tech.
ROCK2 Kinase Activity Assay
IC50
34.0±n/a nM
Citation
 CHENG, CL; ZHAO, Y; WANG, H; ZHONG, W; LI, J; ZHAO, J; LIU, W METHOD FOR TREATING GRAFT VERSUS HOST DISEASE CAUSED BY HEMATOPOIETIC STEM CELL TRANSPLANTATION US Patent  US20230285393 Publication Date 9/14/2023
Target
Name:
Rho-associated protein kinase 2 [1-119]
Synonyms:
KIAA0619 | ROCK2 | ROCK2 (aa 1-119) | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13160.63
Organism:
Homo sapiens (Human)
Description:
O75116[1-119]
Residue:
119
Sequence:
MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYA
  
Inhibitor
Name:
BDBM402405
Synonyms:
US10329282, Compound TDI01434 | US11390609, Compound TDI01434 | US20230285393, Compound 006
Type:
Small organic molecule
Emp. Form.:
C25H19F2N7O
Mol. Mass.:
471.4615
SMILES:
FC1(F)CN(C1)C(=O)c1cc2ccc(cc2[nH]1)-c1nccc(Nc2ccc(cc2)-c2cn[nH]c2)n1
Structure:
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