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Target
Aurora kinase B [1-341]
Ligand
BDBM311131
Substrate
n/a
Meas. Tech.
Aurora B Kinase Test
IC50
20155±n/a nM
Citation
 Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent  US10155751 Publication Date 12/18/2018
Target
Name:
Aurora kinase B [1-341]
Synonyms:
AIK2 | AIM1 | AIRK2 | ARK2 | AURB (aa 1-341) | AURKB | AURKB_HUMAN | STK1 | STK12 | STK5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39070.43
Organism:
Homo sapiens (Human)
Description:
Q96GD4[1-341]
Residue:
341
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQ
  
Inhibitor
Name:
BDBM311131
Synonyms:
US10155751, Example 18
Type:
Small organic molecule
Emp. Form.:
C21H27N5O2
Mol. Mass.:
381.4714
SMILES:
CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2c(C)n(C)nc2c1 |r|
Structure:
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