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Target
Lysophosphatidic acid receptor 1
Ligand
US11912686, Compound 261
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
EC50
11.9±n/a nM
Citation
 Bestvater, BP; Farand, J; Tang, DT; Yang, KS LPA receptor antagonists and uses thereof US Patent  US11912686 Publication Date 2/27/2024
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
US11912686, Compound 261
Synonyms:
n/a
Type:
Small organic molecule
Emp. Form.:
C23H16F6N8O3
Mol. Mass.:
566.4154
SMILES:
C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(NC(=O)c2ccnc(c2F)C(F)(F)F)cn1)c1cc(F)cnc1F |r|
Structure:
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