Reaction Details  Report a problem with these data
Target
Lysophosphatidic acid receptor 1
Ligand
BDBM654367
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
EC50
2.90±n/a nM
Citation
 Bestvater, BP; Farand, J; Tang, DT; Yang, KS LPA receptor antagonists and uses thereof US Patent  US11912686 Publication Date 2/27/2024
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM654367
Synonyms:
Preparation of (R)-1-(2,5-difluoropyridin-3-yl)ethyl (1-methyl-4-(6-methyl-5-(2-(trifluoromethyl)pyrimidine-5-carboxamido)pyridin-2-yl)-1H-1,2,3-triazol-5-yl)carbamate | US11912686, Compound 314
Type:
Small organic molecule
Emp. Form.:
C23H18F5N9O3
Mol. Mass.:
563.4395
SMILES:
C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(NC(=O)c2cnc(nc2)C(F)(F)F)c(C)n1)c1cc(F)cnc1F |r|
Structure:
Search PDB for entries with ligand similarity: